Beilstein J. Org. Chem.2020,16, 638–644, doi:10.3762/bjoc.16.60
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Scale-up experiment to 4a and further synthetic transformations.
Representative screening results of the asymmetricaziridination reaction of PhSO2CF2CHN2.a
Supporting Information
Supporting Information File 244: Experimental procedures, compound characterization, NMR spectra of all new compounds, and
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Graphical Abstract
Scheme 1:
Preparation of chiral aziridines from fluorinated diazo reagents.
Beilstein J. Org. Chem.2014,10, 1282–1289, doi:10.3762/bjoc.10.129
Jingran Tao Li-Mei Jin X. Peter Zhang Department of Chemistry, University of South Florida, Tampa, Florida 33620, USA 10.3762/bjoc.10.129 Abstract The Co(II) complex of a new D2-symmetric chiral porphyrin 3,5-DiMes-QingPhyrin, [Co(P6)], can catalyze asymmetricaziridination of alkenes with bis
85% ee). In addition to mild reaction conditions and generation of N2 as the only byproduct, this new metalloradical catalytic system is highlighted with a practical protocol that operates under neutral and non-oxidative conditions.
Keywords: asymmetricaziridination; aziridine; chiral porphyrin
aryl azides have been effectively employed for metal-catalyzed asymmetricaziridination [16][17][18][19], the catalytic system based on other types of azides, such as phosphoryl azides, remains underdeveloped.
Phosphoryl azides, a family of common organic azides that can be directly synthesized from
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Graphical Abstract
Scheme 1:
[Co(TPP)]-catalyzed olefin aziridination with DPPA.